Memorial Drive and Storrow Drive both have low bridges that frequently snag trucks. So it appears that the best route for a truck to the Hyatt Regency Boston/Cambridge hotel from the Interstates to the Hyatt's loading dock on Vassar St is:
Mass Pike (I-90):- Take Mass Pike to Exit 131 (old exits 18 (East Bound) or 20 (West Bound))
- Go toward Cambridge (cross the river)
- Follow River Street to Central Square (0.7 miles)
- Turn right on Mass Ave
- Turn right on Vassar Street (0.6 miles, immediately after the train tracks)
- Turn left immediately after the Hyatt's parking garage (0.7 miles).
Link to route in Google Maps. From Google Maps, you can send the route to your phone.
If you're coming from North or South of Boston, take I-93 to the Mass Pike and then follow the Mass Pike directions above.
View Arisia Truck Route in a larger map
The red triangles indicate the locations of low bridges on Memorial Drive near the Hyatt.